POLYNUCLEOTIDES
Polynucleotides have gained a significant amount of attention because they are made from highly purified fragments of RNA and DNA from salmon or trout sperm, which stimulate the production of collagen and hyaluronic acid in human skin. More specifically, polynucleotides are injectable biostimulators, which means they work at a cellular level to encourage the skin to rejuvenate itself. They are also anti-inflammatory and are particularly good for treating dark circles around the eyes – an area which can be hard to treat without potential future complications.
Specifically, polynucleotides (PNs) are natural polymers composed of nucleotide monomers, which have been shown to be biocompatible and highly effective in promoting skin health. A natural polymer is a substance made up of long, repeated chains, much like a string of pearls, with the whole string being the polymer. The nucleotide monomers can be thought of as each individual pearl comprising the string, a single building block that makes up DNA and RNA. They work by stimulating the skin’s natural repair mechanisms, making them an excellent option for addressing various aesthetic concerns.
To achieve their effect, polynucleotides need to be injected beneath the skin’s surface using a fine needle. Once there, instead of directly adding volume to the skin, they work as biostimulators, targeting the fibroblasts, which play a crucial role in collagen production and wound healing. By doing so, they encourage our skin to regenerate itself from the inside out, promoting the synthesis of both collagen and elastin and improving the condition of the extracellular matrix [the layer of the skin in which the fibroblasts live]. This results in boosted hydration, reduced inflammation, and improved texture, tone, and firmness, meaning less visible fine lines and wrinkles over time.
They aren’t finished there. Polynucleotides also scavenge up unstable molecules, called free radicals, which further helps to counteract skin ageing. In short, polynucleotides function primarily by:
• Enhancing Cell Regeneration: stimulating fibroblasts, the cells responsible for producing collagen and elastin, thereby improving skin elasticity and texture.
• Promoting Hydration: PNs attract water molecules, creating a hydrated environment that supports cell function.
• Reducing Inflammation: They have anti-inflammatory properties, making them suitable for sensitive or compromised skin.
• Skin rejuvenation and hydration
• Treatment of fine lines and wrinkles
• Scar revision, including acne scars
• Management of skin conditions like rosacea
Polynucleotides can be beneficial for those who are experiencing not only early signs of ageing, but also more advanced ageing concerns, as well as skin damage and trauma. They can assist in the recovery of the following skin conditions:
- Initial and more advanced signs of skin ageing (fine lines, deeper wrinkles, skin laxity and dehydration)
- Scars (acne scars, physical trauma or surgical scars)
- Hair loss and hair thinning (androgenic alopecia)
- Assisting wound healing after surgical procedures
- Hyperpigmentation / sun-damage
- Stretch marks
- Skin disorders such as Rosacea (polynucleotides have shown anti-inflammatory properties which can help reduce redness, irritation and swelling)
- Dark circles—polynucleotide treatment can be a good alternative choice to tear trough fillers
The crux of the experience depends on your tolerance to needles. As with any injection-based treatment, there are quite a few pin-pricks, which are not especially painful individually. But there will be quite a few of them per treatment session. Also, it is generally a three to four treatment plan, a month apart, to get the full benefit.
In comparison to some other injectable skin boosters, it can take a few months before any results are obvious, with polynucleotide improvements occurring relatively quickly. These include better skin tone, greater hydration, and reduced inflammation. There can be a reduction in static wrinkles and crepiness over the course of treatments. At the actual time of injections, you may have a red face and some little raised blebs, like a bee sting. These reduce and calm over the next 24 hours, but it is wise to schedule any PN treatment for a good 7 to 14 days before any special event.
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